The Data is Very Strong: Marijuana Plant Extract Stops Cancers From Spreading

The Data is Very Strong: Marijuana Plant Extract Stops Cancers From Spreadingby MARCO TORRES

The data is very strong and there’s no toxicity associated with A compound found in cannabis could halt the spread of many forms of aggressive cancer, scientists say.

The first research to show marijuana’s anti-tumor properties was presented at the American Association for Cancer Research meeting in Los Angeles in 2007 demonstrating that THC may activate biological pathways that halt cancer cell division or block development of blood vessels that feed tumors. It then became a target of synthetic research into THC for drugs such as ImClone System Inc.’s Erbitux and Amgen Inc.’s Vectibix.

Researchers have now found that the compound, called cannabidiol, had the ability to ‘switch off’ the gene responsible for metastasis in an aggressive form of breast cancer. Importantly, this substance does not produce the psychoactive properties of the cannabis plant.

The team from the California Pacific Medical Center, in San Francisco, first spotted its potential five years ago, after it stopped the proliferation of human breast cancer cells in the lab.

Last year they published a study that found a similar effect in mice. Now they say they are on the verge of publishing further animal study results that expand these results further.

Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. CBD (Cannabidiol), one of the main constituents of the cannabis plant has been proven medically to relieve many diseases including the inhibition of cancer cell growth. Recent studies have shown it to be an effective atypical anti-psychotic in treating schizophrenia. CBD also interferes with the amount of THC your brain processes, balancing the psychotropic effect of marijuana. That is precisely why the power of raw cannabis is turning heads.

Speaking to the San Francisco Chronicle, study co-leader Dr Sean McAllister, said: ‘The preclinical trial data is very strong, and there’s no toxicity. There’s really a lot or research to move ahead with and to get people excited.’

While he, along with colleague Dr Pierre Desprez acknowledge that they are some way off from turning their finding into a pill, they are already developing human trial models. They hope to eventually test the drug in combination with current chemotherapies.

Professor Desprez had previously found that a protein called ID-1 seemed to play a role in causing breast cancer to spread. Meanwhile Dr McAllister had discovered the cannabidiol had anti-cancer potential.
The pair teamed up to see if they could treat a particularly aggressive form of breast cancer called ‘triple negative.’ This form, which affects 15 per cent of patients, doesn’t have three hormone receptors that the most successful therapies target. Cells from this cancer have high levels of ID-1.

When they exposed cells from this cancer to cannabidiol they were shocked to find the cells not only stopped acting ‘crazy’ but also returned to a healthy normal state.

They discovered that the compound had turned off the overexpression of ID-1, stopping them from travelling to distant tissues.

Other potentially treatable cancers are forms of leukaemia, lung, ovarian and brain cancers, which also have high levels of ID-1.

Dr Desprez has a particular reason for wanting to create a treatment as quickly as possible – his sister was recently diagnosed with aggressive breast cancer at the age of 41.

Her condition is currently receptive to hormone therapies but Professor Desprez fears it could recur in a form that lacks hormone receptors.

He said: ‘I want to be ready for that. There is a deadline.’

Cannabis is a Class B drug that is illegal to have, give away or sell. “If cannabis were discovered in an Amazon rainforests today, people would be clambering to make as much use as they could out of the potential benefits of the plant,” said Donald L. Abrams, MD, Chief of Hematology and Oncology at San Francisco General Hospital and Professor of Medicine at the University California. Dr. Abrams is widely known for his research on medical cannabis applications. “Unfortunately, it carries with it a long and not so long history of being a persecuted plant,” he added.

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4 Responses to "The Data is Very Strong: Marijuana Plant Extract Stops Cancers From Spreading"

  1. Kay Lee  September 29, 2012 at 3:22 pm

    I cannot begin to express the anger I feel that the stupidity of politics has become so all encompassing that nothing can trump it, not science, not history, not nature, not common sense… not even the will of the people. I am passionate about the freedom to use this plant for many reasons, the main one being the quality of life sick people are being denied. I don’t care what ‘side’ you take, but please, do something, anything to stimulate discussion about the Cannabis plant. If the buzz becomes loud enough maybe it will drown out the political rhetoric.

  2. Mindaugas Vaitiekūnas  September 30, 2012 at 10:06 am

    Calm down! The government doesn’t need healthy and sober-minded people. Only slaves are needed.

  3. MihaB  October 3, 2012 at 4:18 pm

    I agree with both of you.

  4. Dave the Whistler  October 3, 2012 at 8:09 pm

    Great article, and don’t take this the wrong way because I appreciate the positive portrayal of cannabis here, but even so I think there are a couple inaccuracies in this article:

    1. This isn’t the first research on this matter. The US Federal government has known since 1974 that naturally occurring compounds in marijuana may hold the key to curing cancer. They have been keeping this a secret for decades.

    2. The implication of toxicity in THC in the following: “…toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention.” Can you cite a source, any source, that shows that psychoactive substances in cannabis have a harmful level of toxicity, even when given in high (therapeutic) doses? In spite of scare tactics about how much more potent today’s cannabis is than the cannabis from a generation ago in terms of THC content, we have Marinol which is 100% THC and it’s FDA approved and I believe there have been only two documented deaths from it in all these years. Compare this to any other FDA approved drug in existence–most have killed tens of thousands or hundreds of thousands of people–and note natural marijuana with zero overdose deaths in all of recorded history, over literally thousands of years of human use. THC is extremely non-toxic. According to DEA Administrative Law Judge Francis L. Young, marijuana in its natural form is one of the safest therapeutically active substances known to man, being less toxic to humans than raw potatoes. Yes, that’s right, someone working for the DEA actually said that. Read the court’s findings of fact yourself, from the 1988 legal ruling that the government has been keeping a secret ever since.

    It is a crime against humanity that they are keeping this plant illegal when there is so much evidence that it’s not only not dangerous, but it’s beneficial. The pharmaceutical companies, petroleum companies, alcohol industry, and the prison industrial complex will all lose tons of money (billions of dollars per year) and this is why it is still illegal. We must fight the money of these special interests and the political corruption they buy with their campaign contributions. We must fight this crime by spreading the truth.


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