12. Try SAM-e

SAM-e is short for S-adenosylmethionine. This supplement is designed to act like a synthetic form of the body’s natural mood-boosting chemicals to aid in depression. SAM-e is regarded as a supplement in the United States — the FDA doesn’t consider it a medication.

You should not take SAM-e along with antidepressants. There are mild possible side effects if taking too much SAM-e such as upset stomach and constipation. These will stop if you reduce the dose. Consult your nutritionist.